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ZytoLight ® SPEC VHL/CEN 3 Dual Color Probe

The ZytoLight ® SPEC VHL/CEN 3 Dual Color Probe is designed for the detection of deletions affecting the VHL gene. The tumor suppressor gene VHL (von Hippel-Lindau) is located on 3p25.3 and encodes a 30 kDa protein with ubiquitin ligase E3 activity. The protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a critical role in the regulation of gene expression by oxygen.

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