ZytoLight ® SPEC VEGFA/CEN 6 Dual Color Probe

The ZytoLight ® SPEC VEGFA/CEN 6 Dual Color Probe is designed for the detection of amplifications involving the chromosomal region 6p21.1 harboring the VEGFA gene (vascular endothelial growth factor A, a.k.a. VEGF, VPF). The VEGFA protein is involved in vascular permeability, angiogenesis, cell migration, and inhibition of apoptosis. In addition, binding of VEGFA to its receptors activates the RAS/MEK/MAPK pathway, thus, leading to mitotic activation.

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