EphA2 (SP169)

Ephrin type-A receptor 2 (EphA2) is a protein-tyrosine kinase in the ephrin receptor subfamily. EphA2 plays a role for angiogenesis and tumor neovascularization. High levels of EphA2 protein expression can be detected in some tumor cells such as breast carcinoma, bladder carcinoma, renal cell carcinoma (RCC), and non-small cell lung carcinoma (NSCLC). Inhibition of EphA2 kinase activity is considered for the treatment of various tumors such as RCC and NSCLC.

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